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IGF-1: 
Substance: Somatomedin C

Information


IGF-1 or insulin-like growth factor 1 is a structural homologue of insulin that exhibits insulin-like activity. IGF-1 is synthesized in the liver and it is bound to carrier proteins that determine it's biological actions. IGF-1 is also the peptide through which growth hormone exerts most of its growth promoting effects. If you raise GH levels in the body, IGF-1 levels will also rise. IGF-1 does have an effect on insulin production in the body. It will lead to a decrease in insulin secretion which at the same time increase insulin sensitivity. IGF-1 is chemically the same as insulin but it is also somewhat different. IGF-1 does not seem to regulate glucose levels in the body like insulin does though. 

As far as bodybuilders are concerned, IGF-1 has several effects. It enhances nitrogen balance while simultaneously promoting fat loss. Bodybuilders are claiming a drop in bodyfat and increases in strength. It also seems to lower LDL cholesterol. IGF-1 also normalizes hypoglycemia and hyperinsulinemia. It stimulates DNA synthesis and cell multiplication. It might stimulate red-blood cell production thereby increasing endurance. This action would be similar to what EPO does for the body as well (see EPO description). It is about 3 times less effective in this process as EPO in that respect. EPO has bee used for years to increase oxygen utilization efficiency. Bodybuilders have also found that IGF-1 reacts synergistically with long duration testosterone's as well.

This product is very hard to get ahold of as well. Most people will probably never even see a vial of this stuff. It is only made by three pharmaceutical companies in the world.  

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