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Substance: Gamma Hydroxy Butyrate


GHB (Gamma-hydroxybutyrate) is both a metabolite and precursor of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid, or gamma-aminobutyrate), another nutrient to which it bears a close structural relationship. GHB, however, does not act directly on GABA receptor sites. It is has come to be used in Europe as a general anesthetic, a treatment for insomnia and narcolepsy (a daytime sleeping disorder), an aid to childbirth (increasing strength of contractions, decreasing pain, and increasing dilation of the cervix), a treatment for alcoholism and alcohol withdrawal syndrome, and for many other uses. 

During the 1980s, GHB was widely available over-the-counter in health-food stores, purchased largely by body-builders for its ability to stimulate growth hormone release which aids in fat reduction and muscle building. Later it gained popularity as a "recreational" drug. GHB was been banned from over-the-counter sale by the FDA as of November 8th, 1990. 

Side Effects: Those most commonly experienced are drowsiness, dizziness, nausea, and sometimes vomiting. As a sedative-hypnotic, GHB's effects bear some similarity to those of alcohol and tranquilizers. GHB not only "may cause drowsiness". As mentioned, clonic movements (muscle contractions or "seizures") have been observed during the onset of GHB-induced sleep. Headache is sometimes reported. A slowing of the heart rate is a consistent effect, and small changes in blood pressure can take place. Likewise, orthostatic hypotension (a sudden drop in blood pressure caused by standing up quickly) has also been reported. Sometimes this is experienced as brief dizziness, and rarely people can briefly lose consciousness. At very high doses, cardiac and respiratory depression can occur. Sufficiently large doses of GHB can cause sudden sedation and loss of consciousness. More reactions have included diarrhea, lack of bladder control, temporary amnesia, and sleepwalking.

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